Computer Laboratory


(Photos on Cambridge exam "lifestyle")

Pietro Lio'

I am a Reader in Computational Biology in the Computer Laboratory which is the department of Computer Science of the University of Cambridge and I am a member of the Artificial Intelligence group of the Computer Laboratory.
I hold one PhD in Complex Systems and Non Linear Dynamics (School of Informatics, dept of Engineering of the University of Firenze, Italy) and one PhD in (Theoretical) Genetics (University of Pavia, Italy).

Office: FC20; tel: +44 (0)1223-763604; E_mail: Pietro.Lio at


Recent Papers

Computational BioMedicine /In silico medicine - journal papers

Pratanwanich, N. and Liò, P. (2014) Pathway-based Bayesian inference of drug-disease interactions. Molecular BioSystems (in press).

Ascolani, G. and Liò, P. (2014) Modeling TGF-beta in early stages of cancer tissue dynamics. Plos One 2014 Feb 20;9(2):e88533

Liò, P. (2013). Pathways to P4 medicine. BIOSIGNALS 2013 - Proceedings of the International Conference on Bio-Inspired Systems and Signal Processing, IS15-IS20.

Capobianco E. and Liò, P. (2013), Comorbidity: a multidimensional approach. Trends in Molecular Medicine 2013 Sep;19(9):515-21

Vicenzi, E., Liò, P., & Poli, G. (2013). The puzzling role of CXCR4 in human immunodeficiency virus infection. Theranostics, 3(1), 18-25. doi:10.7150/thno.5392

Bartocci, E., Liò, P., Merelli, E., & Paoletti, N. (2012). Multiple Verification in Complex Biological Systems: The Bone Remodelling Case Study. T. Comp. Sys. Biology, 14, 53-76. doi:10.1007/978-3-642-35524-0_3

Liò, P., Merelli, E., & Paoletti, N. (2012). Disease processes as hybrid dynamical systems. EPTCS 92, 2012, pp. 152-166. doi:10.4204/EPTCS.92.11

Liò, P., Paoletti, N., Moni, M. A., Atwell, K., Merelli, E., & Viceconti, M. (2012). Modelling osteomyelitis.. BMC Bioinformatics, 13 Suppl 14, S12. doi:10.1186/1471-2105-13-S14-S12

Paoletti, N., Liò, P., Merelli, E., & Viceconti, M. (2012). Multilevel computational modeling and quantitative analysis of bone remodeling. IEEE/ACM Trans Comput Biol Bioinform, 9(5), 1366-1378. doi:10.1109/TCBB.2012.51

MultiOmic data integration - journal papers

Shavit, Y., & Lio', P. (2014). Combining wavelet changepoint and Bayes Factor for analysing chromosomal interactions data. Molecular BioSystems (in press)

Bartoszek, K & Lio', P. (2014)  A Novel algorithm to reconstruct phylogenies using gene frequencies and expression data.  Proceedings of 2014 International Conference on Bioinformatics and Biomedical Technology. Gdansk 14-16 May, 2014.

Shavit, Y., & Lio', P. (2013). CytoHiC: a cytoscape plugin for visual comparison of Hi-C networks. Bioinformatics, 29(9), 1206-1207. doi:10.1093/bioinformatics/btt120

Liò, P., Angelini, C., De Feis, I., & Nguyen, V. A. (2012). Statistical approaches to use a model organism for regulatory sequences annotation of newly sequenced species.. PLoS One, 7(9), e42489. doi:10.1371/journal.pone.0042489

Synthetic Biology Journal papers

C. Angione, G. Carapezza, J. Costanza, P. Lió, and G. Nicosia, Pareto Optimality in Organelle Energy Metabolism Analysis, IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2013

G. Carapezza, R. Umeton, J. Costanza, C. Angione, G. Stracquadanio, A. Papini, P. Lió, G. Nicosia, Efficient Behavior of Photosynthetic Organelles via Pareto Optimality, Identifiability and Sensitivity Analysis, ACS Synthetic Biology Journal, 2(5), 274-288, 2013

Brilli, M., Liò, P., Lacroix, V., & Sagot, M. F. (2013). Short and long-term genome stability analysis of prokaryotic genomes.. BMC Genomics, 14(1), 309. doi:10.1186/1471-2164-14-309

J. Costanza, G. Carapezza, C. Angione, P. Lió, and G. Nicosia, Robust Design of Microbial Strains, Bioinformatics, 28(23), 3097-3104, 2012.

Computational BioNanotechnology

Felicetti, L., Femminella, M., Reali, G., Lio', P. A Molecular Communication System in Blood Vessels for Tumor Detection. ACM NANOCOM 2014

Balasubramaniam, S., & Lio', P. (2013). Multi-hop conjugation based bacteria nanonetworks. IEEE Trans Nanobioscience, 12(1), 47-59. doi:10.1109/TNB.2013.2239657.  Ranked 5th among most popular articles in IEEE Transactions on Nanobioscience

Lio', P., & Balasubramaniam, S. (2012). Opportunistic routing through conjugation in bacteria communication nanonetwork. Nano Communication Networks, 3(1), 36-45.

Balasubramaniam S., Ben-Yehuda S., Pautot S., Jesorka A., Lio' P., Koucheryavy Y. (2013). A Review of Experimental Opportunities for Molecular Communication. Nano Communication Networks, vol. 4, no. 2, June 2013.

C. Angione, G. Carapezza , J. Costanza, P. Lió, and G. Nicosia, "Computing with Metabolic Machines", in Proceedings of Turing100: The Alan Turing Centenary Conference. University of Manchester, UK. June 22-26, 2012, pp. 1-15. Best paper award presented by Sir Roger Penrose

Ethics and Awareness of Genome and ICT technologies

Bianchi, L., Fernandes, P., Pietro Lió, P. Improving Collective Awareness and Education about the Privacy and Ethical Issues Connected with the Genome Technologies. Proceedings of the International Conference on The Future of Education. Florence, Italy 13 - 14 June 2013

Stajano, F., Bianchi, L., Lio', P., Korff, D., Forensic Genomics: kin privacy, driftnets and other open questions. Workshop on Privacy in Electronic Society (WPES), Alexandria (VA), USA, October 2008. See:


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