My research is aimed at quantitative modelling of stem cell dynamics as measured by in vitro and in vivo cell labelling assays. I'm utilising deterministic and stochastic Systems Biology techniques like Differential Equations, Markov Processes, and Agent Based Systems.

Publications

• Estimating Dormant and Active Hematopoietic Stem Cell Kinetics through Extensive Modeling of Bromodeoxyuridine Label-Retaining Cell Dynamics. Richard C. van der Wath and Anne Wilson and Elisa Laurenti and Andreas Trumpp and Pietro Lio'. PLoS ONE 4(9): e6972

• Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair. Anne Wilson, Elisa Laurenti, Gabriela Oser, Richard C. van der Wath, William Blanco-Bose, Maike Jaworski, Sandra Offner, Cyrille F. Dunant, Leonid Eshkind, Ernesto Bockamp, Pietro Lio', H. Robson MacDonald, Andreas Trumpp. Cell - 12 December 2008 (Vol. 135, Issue 6, pp. 1118-1129)

  

• A stochastic single cell based model of BrdU measured Hematopoietic stem cell kinetics. Richard C. van der Wath & Pietro Lio'. Computational Methods in Systems Biology, 6th International Conference, CMSB 2008, Rostock, Germany, October 12-15, 2008. Proceedings. Lecture Notes in Computer Science 5307 Springer 2008, ISBN 978-3-540-88561-0.

• Combining Experimental Evidences from Replicates and Nearby Species Data for Annotating Novel Genomes. Claudia Angelini, Luisa Cutillo, Italia De Feis, Pietro Lio, and Richard C. van der Wath, AIP Conf. Proc. 1028, 277 (2008).

• Bayesian phylogeny on Grid. Richard C. van der Wath, Elizabeth van der Wath, Antonio Carapelli, Francesco Nardi, Francesco Frati and Pietro Lio'. Bioinformatics Research and Development (BIRD) 2008. Vienna, Austria. 
  

• Identifying regulatory sites using neighborhood species. Claudia Angelini, Luisa Cutillo, Italia De Feis, Richard C. van der Wath, Pietro Lio’. Lecture Notes in Computer Science. Volume 4447/2007, Pages1-10.

• Grid Methodology for Identifying Co-Regulated Genes and Transcription Factor Binding Sites. Elizabeth van der Wath, Loukas Moutsianas, Richard C. van der Wath, Alet Visagie, Luciano Milanesi, Pietro Lio‘. IEEE Transactions on Nanobioscience, vol.6, no.2, pp.162-167, June 2007.

Posters

• A Stochastic Multi-Agent model of stem cell proliferation. International Conference on Cellular Automata for Research and Industry. September 2008, Japan.

• Modelling frameworks for stem cell dynamics. The opening symposium of the Welcome Trust Centre for Stem Cell Research in Cambridge. December 2006, Cambridge.

• Transcriptomics and Phylogenetics Applications for the EGEE Grid. Network Tools and Applications in Biology (Nettab) 2006 conference. July 2006, Sardinia.