MacHTTP has only one configuration file called MacHTTP.config, which should be tailored to tweak performance, to enable security features, and to specify the mappings between Mac file types and MIME content types.
If you simply want to run a server with the more common MIME Content Types, with no restrictions on who can access your server, then the settings in the default configuration file that comes with the server will get you started.
MacHTTP allows various performance criteria to be set from it's configuration file, but their setting requires your monitoring of your system to decide their values, and so they are not described here.